- induction of pluripotent stem cells from adult human fibroblasts

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induction of pluripotent stem cells from adult human fibroblasts -


Nov 30, 2007 · Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Takahashi K(1), Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. Author information: (1)Department of Stem Cell Biology, Institute for Frontier Medical Cited by: 17000. Nov 30, 2007 · Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and disease-specific stem cells. We previously reported generation of induced pluripotent stem (iPS) cells, capable of germline transmission, from mouse somatic cells by transduction of four defined transcription factors.Cited by: 17000.

These results are proof of principle that pluripotent stem cells can be generated from somatic cells by the combination of a small number of factors. In the current study, we sought to generate iPS cells from adult human somatic cells by optimizing retroviral transduction in human Cited by: 17000. Aug 25, 2006 · Little is known about factors that induce this reprogramming. Here, we demonstrate induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions. Unexpectedly, Nanog was dispensable.Cited by: 21989.

2007). These results are proof of principle that pluripotent stem cells can be generated from somatic cells by the combination of a small number of factors. In the current study, we sought to generate iPS cells from adult human somatic cells by optimizing retroviral transduction inhumanfibroblasts andsubsequent culture conditions. Oct 12, 2008 · Patient-specific stem cells may be created by reprogramming somatic cells to a pluripotent state. A somatic cell can be reprogrammed by transferring its nucleus into an Cited by: 1598.

Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S. Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and disease-specific stem cells. Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from adult cells. The iPSC technology was pioneered by Shinya Yamanaka’s lab in Kyoto, Japan, who showed in 2006 that the introduction of four specific genes encoding transcription factors could convert adult cells into pluripotent stem cells.